I have use these patches for years. I only had side effects when I was also taking another opioid and antidepressant I weaned myself off those two not got any other problems with patches but my doctor is now going to be upping the dosage for my next prescription

I have tried them several times but the side affects makes me sick, then I get depressed

The patches cause me to get a very sore red patch under them if 7.5 or higher. Takes weeks to heal. Other than that, they are the BEST relief I have found for Ehlers-Danlos bone / muscle pain.